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Poster C74 in Poster Session C - Friday, August 9, 2024, 11:15 am – 1:15 pm, Johnson Ice Rink
Evoked responses and transient beta events reveal the frontal microcircuit dynamics of inhibitory control during response inhibition
Darcy Diesburg1 (), C.J. Abeshaus2, Jan Wessel3, Stephanie Jones1; 1Brown University, 2Scripps College, 3University of Iowa
Frontocentral event-related potentials (FC-ERPs) from human scalp EEG are often used as proxy measures of cognition, but the multiscale mechanisms producing them are poorly understood. To address this gap in the context of response inhibition (RI) in the stop-signal task (SST), we used Human Neocortical Neurosolver’s (HNN) biophysical model of a cortical column under external drive to simulate the microcircuit mechanisms that produce the successful (SS) and failed Stop (FS) FC-ERP, including condition differences in the P2, N2, and P3. Using modeling constrained by empirical ERPs, we predict that the strength and timing of thalamocortical drives at early and late timepoints, respectively, are essential mechanisms underlying SS. Predictions about drive timing align with a theoretical “horse-race model” conceptualization; predictions about drive strength do not. Regulation of early movement-associated activity in SS may be accomplished in part due to GABAb-ergic activity following high-power beta transients known to be increased during SS. These simulations make novel predictions about cortical dynamics of RI, which may generalize to mechanisms of control across contexts.
Keywords: inhibitory control cortical microcircuit event-related potential stop-signal