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Poster B158 in Poster Session B - Thursday, August 8, 2024, 1:30 – 3:30 pm, Johnson Ice Rink
Coordinated Computations for Naturalistic Memory Encoding and Retrieval in Hippocampal subspaces
Dasom Kwon1,2 (), Jungwoo Kim1,2, Seng Bum Michael Yoo1,2,3, Won Mok Shim1,2; 1Sungkyunkwan University, 2Institute of Basic Science, 3Baylor College
Our naturalistic experiences are organized into memories through multiple processes, including novelty encoding, memory formation, and retrieval. However, the neural mechanisms coordinating these processes remain unclear. Using fMRI data obtained during movie-viewing and subsequent narrative recall, we examined hippocampal neural subspaces associated with distinct memory processes and characterized their relationships. Within the hippocampus, novelty subspaces encoding different novelty types demonstrated partial overlap and these overlapping novelty subspaces aligned with the subspace involved in memorability. Following event boundaries, hippocampal states within these subspaces aligned inversely along a shared coding axis, predicting subsequent recall performance. However, this alignment was observed only during encoding, not retrieval. Additionally, we found that these hippocampal subspaces were organized along the hippocampal longitudinal axis. Our results offer mechanistic insights into how the hippocampus dynamically coordinates computations underlying memory encoding and retrieval at a population level.
Keywords: Hippocampus Subspace analysis Memory Naturalistic stimuli