Search Papers | Poster Sessions | All Posters
Poster C71 in Poster Session C - Friday, August 9, 2024, 11:15 am – 1:15 pm, Johnson Ice Rink
Reliable individual differences in brain responses during naturalistic movie viewing
Ma Feilong1 (), Jeremy F. Huckins2, Guo Jiahui3, Maria Ida Gobbini4, James V. Haxby1; 1Dartmouth College, 2Biocogniv Inc, 3University of Texas at Dallas, 4University of Bologna
How brain functional architecture differs across people is a key question in neuroscience. Naturalistic stimuli are instrumental in studying these differences by affording rich experiences during brain imaging. Brain responses to the stimulus can be considered as the sum of responses shared by the group, specific to the individual, and noise. Therefore, when people’s brain responses differ, it is difficult to know whether it’s caused by individuating responses or noise. In this study, we used an fMRI dataset where 100 participants watched the same movie twice, and the repetition enabled separating individual differences from noise. For each cortical vertex, we partitioned the variance of its response time series into three components: shared, idiosyncratic, and noise. The amount of idiosyncratic variance was more prominent than shared variance for much of the cortex, especially lateral and medial prefrontal regions. The only exception was visual and auditory cortices, where shared variance was predominant. Together, these results demonstrate the substantial amount of idiosyncratic brain responses to naturalistic stimuli and the great potential to use these responses to study individual differences in cortical functional architecture.
Keywords: naturalistic imaging individual differences precision neuroscience brain functional organization