Search Papers | Poster Sessions | All Posters
Poster A3 in Poster Session A - Tuesday, August 6, 2024, 4:15 – 6:15 pm, Johnson Ice Rink
Beta Oscillations Mediate Responses to Counterfactual Feedback During Decision-Making
Alexandra Fink1 (), Salman Qasim2,3, Jacqueline Overton2, Lizbeth Nunez2, Xiaosi Gu3, Ignacio Saez2,3,4,5; 1Nash Family Department of Neuroscience and the Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 2The Nash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, 3The Center for Computational Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 4Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, 5Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY
Counterfactual information is integral for optimal value-based decision-making. Counterfactuals are mental representations of alternative, hypothetical outcomes, which allow individuals to evaluate chosen and unchosen decisions. Aberrant counterfactual thinking is associated with multiple psychiatric disorders, like depression. While the neural encoding of counterfactual outcomes is well-defined, the neural and behavioral correlates of how counterfactual feedback affects future decision-making is unknown. Using human intracranial electrophysiology, we show the influence of counter-factual feedback on choice behavior is mediated by beta oscillations in the anterior insula and amygdala. These results provide a potential oscillatory mechanism for how previous counterfactual reward outcomes influence future decisions.
Keywords: counterfactual thinking value-based choice human intracranial electrophysiology beta oscillations